The potential role of the osteopontin-osteocalcin-osteoprotegerin triad in the pathogenesis of prediabetes in humans.

ABSTRACT:

Aims

To examine the relationship between hormones involved in bone remodeling and glucose metabolism alterations in prediabetes.

Methods

Individuals (n = 43) with NGT (BMI = 31.1 ± 1.1 kg/m²) and individuals (n = 79) with impaired glucose regulation (IGR) (BMI = 31.9 ± 1.2 kg/m²) including subjects with IFG, IGT, and IFG-IGT underwent OGTT and DXA. Osteopontin (OPN), osteocalcin (OCN), osteoprotegerin (OPG), and PTH levels were measured at fasting. Beta-cell function was calculated using C-peptide deconvolution. Dynamic indexes of insulin sensitivity were calculated from OGTT. A subgroup underwent to a euglycemic hyperinsulinemic clamp with 3-³H-glucose to estimate the endogenous glucose production (EGP) and insulin-mediated body glucose disp

SUBMITTER: Daniele G 

PROVIDER: S-EPMC5816090 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature