Brain-state dependent astrocytic Ca²⁺ signals are coupled to both positive and negative BOLD-fMRI signals.

ABSTRACT: Astrocytic Ca²⁺-mediated gliovascular interactions regulate the neurovascular network in situ and in vivo. However, it is difficult to measure directly both the astrocytic activity and fMRI to relate the various forms of blood-oxygen-level-dependent (BOLD) signaling to brain states under normal and pathological conditions. In this study, fMRI and GCaMP-mediated Ca²⁺ optical fiber recordings revealed distinct evoked astrocytic Ca²⁺ signals that were coupled with positive BOLD signals and intrinsic astrocytic Ca²⁺ signals that were coupled with negative BOLD signals. Both evoked and intrinsic astrocytic calcium signal could occur concurrently or respectively during stimulation. The intrinsic astrocytic calcium signal can be detected globally in mul

SUBMITTER: Wang M 

PROVIDER: S-EPMC5816146 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature