Wireless optoelectronic photometers for monitoring neuronal dynamics in the deep brain.

ABSTRACT: Capabilities for recording neural activity in behaving mammals have greatly expanded our understanding of brain function. Some of the most sophisticated approaches use light delivered by an implanted fiber-optic cable to optically excite genetically encoded calcium indicators and to record the resulting changes in fluorescence. Physical constraints induced by the cables and the bulk, size, and weight of the associated fixtures complicate studies on natural behaviors, including social interactions and movements in environments that include obstacles, housings, and other complex features. Here, we introduce a wireless, injectable fluorescence photometer that integrates a miniaturized light source and a photodetector on a flexible, needle-shaped polymer support, suitable for injection into th

SUBMITTER: Lu L 

PROVIDER: S-EPMC5816195 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature