Kinesin and Dynein Mechanics: Measurement Methods and Research Applications.

ABSTRACT: Motor proteins play critical roles in the normal function of cells and proper development of organisms. Among motor proteins, failings in the normal function of two types of proteins, kinesin and dynein, have been shown to lead many pathologies, including neurodegenerative diseases and cancers. As such, it is critical to researchers to understand the underlying mechanics and behaviors of these proteins, not only to shed light on how failures may lead to disease, but also to guide research toward novel treatment and nano-engineering solutions. To this end, many experimental techniques have been developed to measure the force and motility capabilities of these proteins. This review will (a) discuss such techniques, specifically microscopy, atomic force microscopy (AFM), optical trapping, and

SUBMITTER: Abraham Z 

PROVIDER: S-EPMC5816248 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature