Transcriptional regulation of ependymal cell maturation within the postnatal brain.

ABSTRACT:

Background

Radial glial stem cells within the developing nervous system generate a variety of post-mitotic cells, including neurons and glial cells, as well as the specialised multi-ciliated cells that line the walls of the ventricular system, the ependymal cells. Ependymal cells separate the brain parenchyma from the cerebrospinal fluid and mediate osmotic regulation, the flow of cerebrospinal fluid, and the subsequent dispersion of signalling molecules via the co-ordinated beating of their cilia. Deficits to ependymal cell development and function have been implicated in the formation of hydrocephalus, but the transcriptional mechanisms underpinning ependymal development remain poorly characterised.

Findings

Here, we demonstrate that the transcription factor nuclear factor

SUBMITTER: Vidovic D 

PROVIDER: S-EPMC5816376 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature