Whole exome sequencing reveals novel somatic alterations in neuroblastoma patients with chemotherapy.

ABSTRACT:

Background

We ought to explore the acquired somatic alterations, shedding light on genetic basis of somatic alterations in NB patients with chemotherapy.

Methods

Marrow blood samples from NB patients were collected before treatment, after the 2nd and 4th chemotherapy for baseline research and continuous monitoring by whole exome sequencing. Plasma cell free DNA (cfDNA) was prepared for baseline research. Finger nail cells were extracted as self control. The clinical data was analyzed.

Results

From December 2014 to February 2016, 27 cases of children with stage IV NB were diagnosed. The follow up time ranged from 5 to 25 months, with a median follow up time of 17 months, 20 patients were stable, one patient died of pulmonary embolism during surgery, six patients died o

SUBMITTER: Duan C 

PROVIDER: S-EPMC5816515 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature