A Microvascularized Tumor-mimetic Platform for Assessing Anti-cancer Drug Efficacy.

ABSTRACT: Assessment of anti-cancer drug efficacy in in vitro three-dimensional (3D) bioengineered cancer models provides important contextual and relevant information towards pre-clinical translation of potential drug candidates. However, currently established models fail to sufficiently recapitulate complex tumor heterogeneity. Here we present a chip-based tumor-mimetic platform incorporating a 3D in vitro breast cancer model with a tumor-mimetic microvascular network, replicating the pathophysiological architecture of native vascularized breast tumors. The microfluidic platform facilitated formation of mature, lumenized and flow-aligned endothelium under physiological flow recapitulating both high and low perfused tumor regions. Metastatic and non-metastatic breast cancer cells were maintained in

SUBMITTER: Pradhan S 

PROVIDER: S-EPMC5816595 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature