IL-2 Inducible Kinase ITK is Critical for HIV-1 Infection of Jurkat T-cells.

ABSTRACT: Successful replication of Human immunodeficiency virus (HIV)-1 depends on the expression of various cellular host factors, such as the interleukin-2 inducible T-cell kinase (ITK), a member of the protein family of TEC-tyrosine kinases. ITK is selectively expressed in T-cells and coordinates signaling pathways downstream of the T-cell receptor and chemokine receptors, including PLC-1 activation, Ca²⁺-release, transcription factor mobilization, and actin rearrangements. The exact role of ITK during HIV-1 infection is still unknown. We analyzed the function of ITK during HIV-1 replication and showed that attachment, fusion of virions with the cell membrane and entry into Jurkat T-cells was inhibited when ITK was knocked down. In contrast, reverse transcription and provirus expressi

SUBMITTER: Hain A 

PROVIDER: S-EPMC5816632 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature