Structural determinants of the SINE B2 element embedded in the long non-coding RNA activator of translation AS Uchl1.

ABSTRACT: Pervasive transcription of mammalian genomes leads to a previously underestimated level of complexity in gene regulatory networks. Recently, we have identified a new functional class of natural and synthetic antisense long non-coding RNAs (lncRNA) that increases translation of partially overlapping sense mRNAs. These molecules were named SINEUPs, as they require an embedded inverted SINE B2 element for their UP-regulation of translation. Mouse AS Uchl1 is the representative member of natural SINEUPs. It was originally discovered for its role in increasing translation of Uchl1 mRNA, a gene associated with neurodegenerative diseases. Here we present the secondary structure of the SINE B2 Transposable Element (TE) embedded in AS Uchl1. We find that specific structural regions, containing a sh

SUBMITTER: Podbevsek P 

PROVIDER: S-EPMC5816658 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature