Use of self-collected capillary blood samples for islet autoantibody screening in relatives: a feasibility and acceptability study.

ABSTRACT:

Aims

To evaluate the feasibility of using self-collected capillary blood samples for islet autoantibody testing to identify risk in relatives of people with Type 1 diabetes.

Methods

Participants were recruited via the observational TrialNet Pathway to Prevention study, which screens and monitors relatives of people with Type 1 diabetes for islet autoantibodies. Relatives were sent kits for capillary blood collection, with written instructions, an online instructional video link and a questionnaire. Sera from capillary blood samples were tested for autoantibodies to glutamic acid decarboxylase, islet antigen-2, insulin and zinc transporter 8. 'Successful' sample collection was defined as obtaining sufficient volume and quality to provide definitive autoantibody results, inclu

SUBMITTER: Liu Y 

PROVIDER: S-EPMC5816681 | biostudies-literature | 2017 Jul

REPOSITORIES: biostudies-literature