In silico interaction analysis of cannabinoid receptor interacting protein 1b (CRIP1b) - CB1 cannabinoid receptor.

ABSTRACT: Cannabinoid Receptor Interacting Protein isoform 1b (CRIP1b) is known to interact with the CB₁ receptor. Alternative splicing of the CNRIP1 gene produces CRIP1a and CRIP1b with a difference in the third exon only. Exons 1 and 2 encode for a functional domain in both proteins. CRIP1a is involved in regulating CB₁ receptor internalization, but the function of CRIP1b is not very well characterized. Since there are significant identities in functional domains of these proteins, CRIP1b is a potential target for drug discovery. We report here predicted structure of CRIP1b followed by its interaction analysis with CB₁ receptor by in-silico methods A number of complementary computational techniques, including, homology modeling, ab-initio and protein threading, wer

SUBMITTER: Singh P 

PROVIDER: S-EPMC5816684 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature