Factors associated with distant recurrence following R0 lobectomy for pN0 lung adenocarcinoma.

ABSTRACT:

Objective

We investigated factors associated with distant recurrence, disease-free survival (DFS), and overall survival (OS) following R0 lobectomy for pathologic node-negative (pN0) lung adenocarcinoma.

Methods

We performed a retrospective analysis of a prospectively maintained database of patients with pT1-3N0M0 non-small cell lung cancer. Exclusion criteria included metachronous lung cancer, sublobar/incomplete resection, nonadenocarcinoma histology, and induction/adjuvant therapy. The primary outcome was distant recurrence; secondary outcomes were DFS and OS. Associations between variables and outcomes were assessed by Fine-Gray competing-risk regression for distant recurrence and Cox proportional hazard models for DFS and OS.

Results

Of 2392 patients identified w

SUBMITTER: Brandt WS 

PROVIDER: S-EPMC5816702 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature