Aerobic reactions of antitumor active dirhodium(II) tetraacetate Rh2(CH3COO)4 with glutathione.

ABSTRACT: The aerobic reaction between glutathione (H3A) and dirhodium(II) tetraacetate, Rh2(AcO)4 (AcO- = CH3COO-), in aqueous solution (pH 7.4) breaks up the direct RhII-RhII bond and its carboxylate framework, as evidenced by UV-Vis spectroscopy. After purifying the reaction product using size exclusion chromatography, electrospray ionization mass spectrometry (ESI-MS) of the solution showed binuclear [Formula: see text] and [Formula: see text] ions. Evaporation yielded a solid compound, [Formula: see text], for which Rh K-edge extended X-ray absorption fine structure (EXAFS) spectroscopy revealed ~ 2 Rh-O (2.08 ± 0.02 Å) and ~ 4 Rh-S (2.33 ± 0.02 Å) bond distances around each RhIII center, and the RhIII··RhIII distance 3.11 ± 0.02 Å, close to that in dirhodium(III) complexes with three bridging

SUBMITTER: Enriquez Garcia A 

PROVIDER: S-EPMC5816706 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature