Novel polymorphisms associated with hyperalphalipoproteinemia and apparent cardioprotection.

ABSTRACT:

Background

Hyperalphalipoproteinemia (HALP) is inversely correlated with coronary heart disease (CHD) although genetic variants associated with high serum levels of high-density lipoprotein cholesterol (HDL-C) have not been shown to be cardioprotective.

Objective

The objective of the study was to uncover novel genetic variants associated with HALP and possibly with reduced risk of CHD.

Methods

Exome sequencing data, HDL-C, and triglyceride levels were analyzed in 1645 subjects. They included the University of Maryland outpatients with high HDL-C (n = 12), Cardiovascular Health Study (n = 210), Jackson Heart Study (n = 402), Multi-Ethnic Study of Atherosclerosis (n = 404), Framingham Heart Study (n = 463), and Old Order Amish (n = 154).

Results

Novel nonsynonymo

SUBMITTER: Oates CP 

PROVIDER: S-EPMC5816714 | biostudies-literature | 2018 Jan - Feb

REPOSITORIES: biostudies-literature