Responsivity of Periaqueductal Gray Connectivity Is Related to Headache Frequency in Episodic Migraine.

ABSTRACT: Migraineurs show hypersensitivity to sensory stimuli at various stages throughout the migraine cycle. A number of putative processes have been implicated including a dysfunction in the descending pain modulatory system in which the periaqueductal gray (PAG) is considered to play a crucial role. Recurring migraine attacks could progressively perturb this system, lowering the threshold for future attacks, and contribute to disease chronification. Here, we investigated PAG connectivity with other brain regions during a noxious thermal stimulus to determine changes in migraineurs, and associations with migraine frequency. 21 episodic migraine patients and 22 matched controls were included in the study. During functional MRI, a thermode was placed on the subjects' temple delivering noxious and

SUBMITTER: Solstrand Dahlberg L 

PROVIDER: S-EPMC5816750 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature