Multitarget Effects of Danqi Pill on Global Gene Expression Changes in Myocardial Ischemia.

ABSTRACT: Danqi pill (DQP) is a widely prescribed traditional Chinese medicine (TCM) in the treatment of cardiovascular diseases. The objective of this study is to systematically characterize altered gene expression pattern induced by myocardial ischemia (MI) in a rat model and to investigate the effects of DQP on global gene expression. Global mRNA expression was measured. Differentially expressed genes among the sham group, model group, and DQP group were analyzed. The gene ontology enrichment analysis and pathway analysis of differentially expressed genes were carried out. We quantified 10,813 genes. Compared with the sham group, expressions of 339 genes were upregulated and 177 genes were downregulated in the model group. The upregulated genes were enriched in extracellular matrix organization,

SUBMITTER: Wang Q 

PROVIDER: S-EPMC5816862 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature