Preterm Life in Sterile Conditions: A Study on Preterm, Germ-Free Piglets.

ABSTRACT: Preterm infants born with immature organ systems, which can impede normal development, can also be highly sensitive to different biological and/or environmental factors. Animal models could aid in investigating and understanding the effects of different conditions on the health of these immunocompromised infants. The epitheliochorial placentation of the pig prevents the prenatal transfer of protective colostral immunoglobulins. Surgical colostrum-deprived piglets are free of maternal immunoglobulins, and the cells that are normally provided via colostrum. We bred preterm germ-free piglets in sterile conditions and compared them with their term counterparts. Enterocyte development and intestinal morphology, tight junction proteins claudin-1 and occludin, pattern-recognizing receptors

SUBMITTER: Splichalova A 

PROVIDER: S-EPMC5817058 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature