Elucidating Duramycin's Bacterial Selectivity and Mode of Action on the Bacterial Cell Envelope.

ABSTRACT: The use of naturally occurring antimicrobial peptides provides a promising route to selectively target pathogenic agents and to shape microbiome structure. Lantibiotics, such as duramycin, are one class of bacterially produced peptidic natural products that can selectively inhibit the growth of other bacteria. However, despite longstanding characterization efforts, the microbial selectivity and mode of action of duramycin are still obscure. We describe here a suite of biological, chemical, and physical characterizations that shed new light on the selective and mechanistic aspects of duramycin activity. Bacterial screening assays have been performed using duramycin and Populus-derived bacterial isolates to determine species selectivity. Lipidomic profiles of selected resistant and se

SUBMITTER: Hasim S 

PROVIDER: S-EPMC5817074 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature