Functional Characterization of ABCC Proteins from Trypanosoma cruzi and Their Involvement with Thiol Transport.

ABSTRACT: Chagas disease is a neglected disease caused by the protozoan Trypanosoma cruzi and affects 8 million people worldwide. The main chemotherapy is based on benznidazole. The efficacy in the treatment depends on factors such as the parasite strain, which may present different sensitivity to treatment. In this context, the expression of ABC transporters has been related to chemotherapy failure. ABC transporters share a well-conserved ABC domain, responsible for ATP binding and hydrolysis, whose the energy released is coupled to transport of molecules through membranes. The most known ABC transporters are ABCB1 and ABCC1, involved in the multidrug resistance phenotype in cancer, given their participation in cellular detoxification. In T. cruzi, 27 ABC genes were identified in the

SUBMITTER: da Costa KM 

PROVIDER: S-EPMC5817095 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature