Distinct Profiles of CD163-Positive Macrophages in Idiopathic Interstitial Pneumonias.

ABSTRACT:

Background

The types of cells most significantly linked to individual subtypes of idiopathic interstitial pneumonias (IIPs) remain unclear. Few studies have examined CD163⁺ macrophages in IIPs.

Objective

We retrospectively aimed to immunohistochemically characterize the CD163⁺ macrophages in IIPs.

Methods

Paraffin-embedded lung tissue samples were obtained from 47 patients with IIPs, including idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (NSIP), and cryptogenic organizing pneumonia (COP), and 12 normal controls were immunohistochemically analyzed, using primary antibodies against CD68 and CD163 as indicators of pan and M2 macrophages, respectively.

Results

CD68⁺ macrophage density was signif

SUBMITTER: Yamashita M 

PROVIDER: S-EPMC5817286 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature