A systems biology approach to investigate the mechanism of action of trabectedin in a model of myelomonocytic leukemia.

ABSTRACT: This study was designed to investigate the mode of action of trabectedin in myelomonocytic leukemia cells by applying systems biology approaches to mine gene expression profiling data and pharmacological assessment of the cellular effects. Significant enrichment was found in regulons of target genes inferred for specific transcription factors, among which MAFB was the most upregulated after treatment and was central in the transcriptional network likely to be relevant for the specific therapeutic effects of trabectedin against myelomonocytic cells. Using the Connectivity Map, similarity among transcriptional signatures elicited by treatment with different compounds was investigated, showing a high degree of similarity between transcriptional signatures of trabectedin and those of the topoi

SUBMITTER: Mannarino L 

PROVIDER: S-EPMC5817395 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature