Effect of Azithromycin on Airflow Decline-Free Survival After Allogeneic Hematopoietic Stem Cell Transplant: The ALLOZITHRO Randomized Clinical Trial.

ABSTRACT:

Importance

Bronchiolitis obliterans syndrome has been associated with increased morbidity and mortality after allogeneic hematopoietic stem cell transplant (HSCT). Previous studies have suggested that azithromycin may reduce the incidence of post-lung transplant bronchiolitis obliterans syndrome.

Objective

To evaluate if the early administration of azithromycin can improve airflow decline-free survival after allogeneic HSCT.

Design, setting, and participants

The ALLOZITHRO parallel-group trial conducted in 19 French academic transplant centers and involving participants who were at least 16 years old, had undergone allogeneic HSCT for a hematological malignancy, and had available pretransplant pulmonary function test results. Enrollment was from February 2014 to Augus

SUBMITTER: Bergeron A 

PROVIDER: S-EPMC5817485 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature