Low-Dose Naltrexone Treatment of Familial Benign Pemphigus (Hailey-Hailey Disease).

ABSTRACT:

Importance

Familial benign pemphigus, or Hailey-Hailey disease (HHD), is a rare and debilitating genetic dermatosis characterized by chronic, recurrent vesicles, erosions, and maceration in flexural areas. Despite the reported therapeutic modalities, such as topical and systemic corticosteroids, systemic immunomodulators, topical and systemic retinoids, and laser, HHD can still be markedly difficult to control.

Objective

To assess low-dose naltrexone hydrochloride in the treatment of recalcitrant HHD.

Design, setting, and participants

In this case series, 3 patients with biopsy-proven recalcitrant HHD were evaluated in the outpatient dermatology clinic at the Cleveland Clinic. Each patient was treated with low-dose naltrexone hydrochloride at a dosage of 1.5 to 3.0 mg

SUBMITTER: Ibrahim O 

PROVIDER: S-EPMC5817587 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature