Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial.

ABSTRACT:

Importance

Guidelines recommend corticosteroids in patients with IgA nephropathy and persistent proteinuria, but the effects remain uncertain.

Objective

To evaluate the efficacy and safety of corticosteroids in patients with IgA nephropathy at risk of progression.

Design, setting, and participants

The Therapeutic Evaluation of Steroids in IgA Nephropathy Global (TESTING) study was a multicenter, double-blind, randomized clinical trial designed to recruit 750 participants with IgA nephropathy (proteinuria greater than 1 g/d and estimated glomerular filtration rate [eGFR] of 20 to 120 mL/min/1.73 m2 after at least 3 months of blood pressure control with renin-angiotensin system blockade] and to provide follow-up until 335 primary outcomes occurred.

Interventions

SUBMITTER: Lv J 

PROVIDER: S-EPMC5817603 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature