DMRfinder: efficiently identifying differentially methylated regions from MethylC-seq data.

ABSTRACT:

Background

DNA methylation is an epigenetic modification that is studied at a single-base resolution with bisulfite treatment followed by high-throughput sequencing. After alignment of the sequence reads to a reference genome, methylation counts are analyzed to determine genomic regions that are differentially methylated between two or more biological conditions. Even though a variety of software packages is available for different aspects of the bioinformatics analysis, they often produce results that are biased or require excessive computational requirements.

Results

DMRfinder is a novel computational pipeline that identifies differentially methylated regions efficiently. Following alignment, DMRfinder extracts methylation counts and performs a modified single-linkage clus

SUBMITTER: Gaspar JM 

PROVIDER: S-EPMC5817627 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature