Atypical antipsychotics, insulin resistance and weight; a meta-analysis of healthy volunteer studies.

ABSTRACT: Atypical antipsychotics increase the risk of diabetes and cardiovascular disease through their side effects of insulin resistance and weight gain. The populations for which atypical antipsychotics are used carry a baseline risk of metabolic dysregulation prior to medication which has made it difficult to fully understand whether atypical antipsychotics cause insulin resistance and weight gain directly. The purpose of this work was to conduct a systematic review and meta-analysis of atypical antipsychotic trials in healthy volunteers to better understand their effects on insulin sensitivity and weight gain. Furthermore, we aimed to evaluate the occurrence of insulin resistance with or without weight gain and with treatment length by using subgroup and meta-regression techniques. Overall, th

SUBMITTER: Burghardt KJ 

PROVIDER: S-EPMC5817633 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature