Ontology highlight
ABSTRACT:
SUBMITTER: Tan CS
PROVIDER: S-EPMC5817792 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Molecular cancer 20180219 1
Acquired T790 M mutation is the commonest cause of resistance for advanced non-small cell lung cancer (NSCLC) epidermal growth factor receptor (EGFR) mutant patients who had progressed after first line EGFR TKI (tyrosine kinase inhibitor). Several third generation EGFR TKIs which are EGFR mutant selective and wild-type (WT) sparing were developed to treat these patients with T790 M acquired resistant mutation. Osimertinib is one of the third generation EGFR TKIs and is currently the most advance ...[more]