Circulating CD3⁺CD4⁺CD161⁺ Cells Are Associated with Early Complications after Autologous Stem Cell Transplantation in Multiple Myeloma.

ABSTRACT: The aim of this study was to explore if measurement of pretransplant circulating CD161-expressing cells, in addition to clinical risk factors, could predict mucositis and infections in patients with multiple myeloma (MM) undergoing autologous stem cell transplantation (ASCT). To determine if CD161-expressing cells are likely to predict early complications, namely, mucositis (≥grade 3), infections, and cytomegalovirus (CMV) reactivation, we prospectively examined CD161-expressing cells (CD3⁺CD4⁺CD161⁺ and CD3⁺CD8⁺CD161⁺) in peripheral blood samples from 108 patients with MM undergoing ASCT. After adjusting for factors identified by univariate analysis that predicted mucositis (≥grade 3), infection before engraftment, and CMV

SUBMITTER: Lee SE 

PROVIDER: S-EPMC5817817 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature