Association between oxidative stress and atrial fibrillation.

ABSTRACT:

Background

Oxidative stress (OS) may be a key mechanism underlying the development of atrial fibrillation (AF) in experimental studies, but data in humans remain limited.

Objective

Systemic OS can be estimated by measurements of circulating levels of the aminothiols including glutathione, cysteine, and their oxidized products. We tested the hypothesis that the redox potentials of glutathione (E_hGSH) and cysteine will be associated with prevalent and incident AF.

Methods

Plasma levels of aminothiols were measured in 1439 patients undergoing coronary angiography, of whom 148 (10.3%) had a diagnosis of AF. After a median follow-up of 6.3 years, 104 of 917 patients (11.5%) developed incident AF. Multivariate logistic regression and Cox regression models were us

SUBMITTER: Samman Tahhan A 

PROVIDER: S-EPMC5817893 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature