Seroprevalence of hepatitis B virus in Taiwan 30 years after the commencement of the national vaccination program.

ABSTRACT:

Background

In this study, the long-term efficacy of hepatitis B virus (HBV) vaccination was assessed using seroprevalence and an age-period-cohort (APC) model of HBV seromarkers among university entrants 30 years after the introduction of the national neonatal HBV vaccination program in Taiwan.

Methods

In total, data of 17,611 university entrants who underwent university entrance health examinations between 2005 and 2016 were included. The seroprevalence of the HBV surface antigen (HBsAg) and the levels of the antibody against the HBV surface antigen (anti-HBs) in each year group and sex were calculated. The levels of the antibody against the HBV core antigen were examined only for 2012 and 2016. The APC model was used to analyze the HBV carrier rates.

Results

The chr

SUBMITTER: Hu YC 

PROVIDER: S-EPMC5817935 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature