Fitness Tradeoffs of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli.

ABSTRACT: Evolutionary trade-offs occur when selection on one trait has detrimental effects on other traits. In pathogenic microbes, it has been hypothesized that antibiotic resistance trades off with fitness in the absence of antibiotic. Although studies of single resistance mutations support this hypothesis, it is unclear whether trade-offs are maintained over time, due to compensatory evolution and broader effects of genetic background. Here, we leverage natural variation in 39 extraintestinal clinical isolates of Escherichia coli to assess trade-offs between growth rates and resistance to fluoroquinolone and cephalosporin antibiotics. Whole-genome sequencing identifies a broad range of clinically relevant resistance determinants in these strains. We find evidence for a negative correlation betwe

SUBMITTER: Basra P 

PROVIDER: S-EPMC5817949 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature