Smoking and Parkinson disease: Evidence for gene-by-smoking interactions.

ABSTRACT:

Objective

To investigate whether cigarette smoking interacts with genes involved in individual susceptibility to xenobiotics for the risk of Parkinson disease (PD).

Methods

Two French population-based case-control studies (513 patients, 1,147 controls) were included as a discovery sample to examine gene-smoking interactions based on 3,179 single nucleotide polymorphisms (SNPs) in 289 genes involved in individual susceptibility to xenobiotics. SNP-by-cigarette smoking interactions were tested in the discovery sample through an empirical Bayes (EB) approach. Nine SNPs were selected for replication in a population-based case-control study from California (410 patients, 845 controls) with standard logistic regression and the EB approach. For SNPs that replicated, we performed po

SUBMITTER: Lee PC 

PROVIDER: S-EPMC5818012 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature