Temporal analysis of hippocampal CA3 gene coexpression networks in a rat model of febrile seizures.

ABSTRACT: Complex febrile seizures during infancy constitute an important risk factor for development of epilepsy. However, little is known about the alterations induced by febrile seizures that make the brain susceptible to epileptic activity. In this context, the use of animal models of hyperthermic seizures (HS) could allow the temporal analysis of brain molecular changes that arise after febrile seizures. Here, we investigated temporal changes in hippocampal gene coexpression networks during the development of rats submitted to HS. Total RNA samples were obtained from the ventral hippocampal CA3 region at four time points after HS at postnatal day (P) 11 and later used for gene expression profiling. Temporal endpoints were selected for investigating the acute (P12), latent (P30 and P60) and chro

SUBMITTER: Azevedo H 

PROVIDER: S-EPMC5818071 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature