Nephron progenitor cell death elicits a limited compensatory response associated with interstitial expansion in the neonatal kidney.

ABSTRACT: The final nephron number in an adult kidney is regulated by nephron progenitor cell availability and collecting duct branching in the fetal period. Fetal environmental perturbations that cause reductions in cell numbers in these two compartments result in low nephron endowment. Previous work has shown that maternal dietary factors influence nephron progenitor cell availability, with both caloric restriction and protein deprivation leading to reduced cell numbers through apoptosis. In this study, we evaluate the consequences of inducing nephron progenitor cell death on progenitor niche dynamics and on nephron endowment. Depletion of approximately 40% of nephron progenitor cells by expression of diphtheria toxin A at embryonic day 15 in the mouse results in 10-20% nephron reduction in the ne

SUBMITTER: Muthukrishnan SD 

PROVIDER: S-EPMC5818074 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature