A randomized study to evaluate the effect of exercise on fatigue in people with relapsing-remitting multiple sclerosis treated with fingolimod.

ABSTRACT:

Background

Fatigue is a major symptom of multiple sclerosis (MS) in patients, and it has been shown to improve with physical exercise. Although fingolimod might lessen fatigue, it is unclear how patients treated with fingolimod react to physical activity regarding fatigue.

Objective

This study evaluated the effect of an exercise intervention on fatigue in relapsing-remitting MS patients receiving fingolimod.

Methods

People with MS (PwMS) were randomized to either a structured internet-based exercise program (e-training) or no e-training intervention. The primary endpoint was the change in the Modified Fatigue Impact Scale (mFIS) after six months.

Results

The primary analysis showed no statistically significant difference between groups in the mFIS change. Subgr

SUBMITTER: Maurer M 

PROVIDER: S-EPMC5818099 | biostudies-literature | 2018 Jan-Mar

REPOSITORIES: biostudies-literature