Genetic influences on cognition in progressive supranuclear palsy.

ABSTRACT:

Background

Cognitive dysfunction is common in progressive supranuclear palsy, but the influence of genetics on cognition in this disorder has not been well studied. The objective of this study was to investigate the effect of genes previously identified as risk alleles, including microtubule-associated protein tau, myelin-associated oligodendrocyte basic protein, eukaryotic translation initiation factor 2-alpha kinase 3, and syntaxin 6, as well as apolipoprotein E, on cognitive function in progressive supranuclear palsy.

Methods

The sample was composed of 305 participants who met criteria for possible or probable progressive supranuclear palsy. Genetic information was determined by TaqMan genotyping assays. A neuropsychological battery was administered to all study participa

SUBMITTER: Gerstenecker A 

PROVIDER: S-EPMC5818145 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature