The effect of white matter hyperintensities on verbal memory: Mediation by temporal lobe atrophy.

ABSTRACT:

Objective

To determine the relationship between white matter hyperintensities (WMH) presumed to indicate disease of the cerebral small vessels, temporal lobe atrophy, and verbal memory deficits in Alzheimer disease (AD) and other dementias.

Methods

We recruited groups of participants with and without AD, including strata with extensive WMH and minimal WMH, into a cross-sectional proof-of-principle study (n = 118). A consecutive case series from a memory clinic was used as an independent validation sample (n = 702; Sunnybrook Dementia Study; NCT01800214). We assessed WMH volume and left temporal lobe atrophy (measured as the brain parenchymal fraction) using structural MRI and verbal memory using the California Verbal Learning Test. Using path modeling with an inferential boo

SUBMITTER: Swardfager W 

PROVIDER: S-EPMC5818160 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature