Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells.

ABSTRACT: Natural killer (NK) cells are innate lymphocytes, important in immune surveillance and elimination of stressed, transformed, or virus-infected cells. They critically shape the inflammatory cytokine environment to orchestrate interactions of cells of the innate and adaptive immune systems. Some studies have reported that NK cell activation and cytokine secretion are controlled epigenetically but have yielded only limited insight into the mechanisms. Using chemical screening with small-molecule inhibitors of chromatin methylation and acetylation, further validated by knockdown approaches, we here identified Jumonji-type histone H3K27 demethylases as key regulators of cytokine production in human NK cell subsets. The prototypic JMJD3/UTX (Jumonji domain-containing protein 3) H3K27 demethylase

SUBMITTER: Cribbs A 

PROVIDER: S-EPMC5818173 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature