Patterns of blood pressure response during intensive BP lowering and clinical events: results from the secondary prevention of small subcortical strokes trial.

ABSTRACT:

Purpose

We applied cluster analysis to identify discrete patterns of concomitant responses of systolic (SBP), diastolic (DBP) and pulse pressure (PP) during intensive BP lowering; and to evaluate their clinical relevance and association with risk of mortality, major vascular events (MVEs), and stroke.

Material and methods

We used an unsupervised cluster procedure to identify distinct patterns of BP change during the first 9 months of anti-hypertensive therapy intensification among 1,331 participants in the Secondary Prevention of Small Subcortical Strokes Trial who were previously randomized to lower BP target (SBP < 130 mm Hg) after lacunar stroke.

Results

The cluster procedure partitioned participants into three groups in the lower SBP target arm, persons with: 1) m

SUBMITTER: Ku E 

PROVIDER: S-EPMC5818304 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature