A hierarchical modeling approach for assessing the safety of exposure to complex antiretroviral drug regimens during pregnancy.

ABSTRACT: Combination antiretroviral regimens have achieved tremendous success in reducing perinatal HIV transmission, and have become standard of care in pregnant women with HIV. However, the large variety of combination antiretroviral regimens utilized in practice raises the question of whether some of these highly potent drugs pose other risks to the pregnancy or infant. While HIV-infected pregnant women are almost always exposed to multiple antiretrovirals concurrently, standard safety screening strategies typically consider each individual antiretroviral separately, which fails to account for potential confounding due to simultaneous exposure to other antiretrovirals. In this paper, we evaluate a hierarchical modeling approach which groups antiretrovirals by drug class to screen for the safety

SUBMITTER: Correia K 

PROVIDER: S-EPMC5818331 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature