T-cell responses against rhinovirus species A and C in asthmatic and healthy children.

ABSTRACT: BACKGROUND:Infections by rhinovirus (RV) species A and C are the most common causes of exacerbations of asthma and a major cause of exacerbations of other acute and chronic respiratory diseases. Infections by both species are prevalent in pre-school and school-aged children and, particularly for RV-C, can cause severe symptoms and a need for hospitalization. While associations between RV infection and asthma are well established, the adaptive immune-mechanisms by which RV infections influence asthma exacerbations are yet to be defined. OBJECTIVE:The aim of this study was to characterize and compare T-cell responses between RV-A and RV-C and to test the hypothesis that T-cell responses would differ between asthmatic children and healthy controls. METHODS:A multi-parameter flow cytometry ass

SUBMITTER: Gaido CM 

PROVIDER: S-EPMC5818445 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature