Exposure of the Amino Terminus of Tau Is a Pathological Event in Multiple Tauopathies.

ABSTRACT: Pathological changes to the tau protein, including conformational changes and aggregation, are major hallmarks of a group of neurodegenerative disorders known as tauopathies. Among the conformational changes are alterations involving the extreme amino terminus of the protein, known as the phosphatase-activating domain (PAD). Aberrant PAD exposure induces a signaling cascade that leads to disruption of axonal transport, a critical function for neuronal survival. Conformational display of PAD is an early marker of pathological tau in Alzheimer disease (AD), but its role in other tauopathies has yet to be firmly established. We used a relatively novel N-terminal, conformation-sensitive antibody, TNT2, to determine whether misfolding in the amino terminus (ie, PAD exposure) occurs in non-AD ta

SUBMITTER: Combs B 

PROVIDER: S-EPMC5818634 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature