Human antibody responses against non-covalently cell wall-bound Staphylococcus aureus proteins.

ABSTRACT: Human antibody responses to pathogens, like Staphylococcus aureus, are important indicators for in vivo expression and immunogenicity of particular bacterial components. Accordingly, comparing the antibody responses to S. aureus components may serve to predict their potential applicability as antigens for vaccination. The present study was aimed at assessing immunoglobulin G (IgG) responses elicited by non-covalently cell surface-bound proteins of S. aureus, which thus far received relatively little attention. To this end, we applied plasma samples from patients with the genetic blistering disease epidermolysis bullosa (EB) and healthy S. aureus carriers. Of note, wounds of EB patients are highly colonized with S. aureus and accordingly these patients are more seriously exposed to staphylo

SUBMITTER: Romero Pastrana F 

PROVIDER: S-EPMC5818649 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature