Gray and white matter integrity influence TMS signal propagation: a multimodal evaluation in cocaine-dependent individuals.

ABSTRACT: Transcranial magnetic stimulation (TMS) can stimulate cortical and subcortical brain regions. However, in order to reach subcortical targets, intact monosynaptic connections are required. The goal of this investigation was to evaluate the contribution of white matter integrity and gray matter volume to frontal pole TMS-evoked striatal activity in a large cohort of chronic cocaine users. 49 cocaine users received single pulses of TMS to the frontal pole while BOLD data were acquired - a technique known as interleaved TMS/fMRI. Diffusion tensor imaging and voxel-based morphometry were used to quantify white matter integrity and gray matter volume (GMV), respectively. Stepwise regression was used to evaluate the contribution of clinical and demographic variables to TMS-evoked BOLD. Consistent

SUBMITTER: Kearney-Ramos TE 

PROVIDER: S-EPMC5818658 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature