CCR8 Expression Defines Tissue-Resident Memory T Cells in Human Skin.

ABSTRACT: Human skin harbors two major T cell compartments of equal size that are distinguished by expression of the chemokine receptor CCR8. In vitro studies have demonstrated that CCR8 expression is regulated by TCR engagement and the skin tissue microenvironment. To extend these observations, we examined the relationship between CCR8⁺ and CCR8^- skin T cells in vivo. Phenotypic, functional, and transcriptomic analyses revealed that CCR8⁺ skin T cells bear all the hallmarks of resident memory T cells, including homeostatic proliferation in response to IL-7 and IL-15, surface expression of tissue localization (CD103) and retention (CD69) markers, low levels of inhibitory receptors (programmed cell death protein 1, Tim-3, LAG-3), and a lack of senescence markers (CD57

SUBMITTER: McCully ML 

PROVIDER: S-EPMC5818732 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature