Computational predictions of cysteine cathepsin-mediated fibrinogen proteolysis.

ABSTRACT: Fibrin clot formation is a proteolytic cascade of events with thrombin and plasmin identified as the main proteases cleaving fibrinogen precursor, and the fibrin polymer, respectively. Other proteases may be involved directly in fibrin(ogen) cleavage, clot formation, and resolution, or in the degradation of fibrin-based scaffolds emerging as useful tools for tissue engineered constructs. Here, cysteine cathepsins are investigated for their putative ability to hydrolyze fibrinogen, since they are potent proteases, first identified in lysosomal protein degradation and known to participate in extracellular proteolysis. To further explore this, we used two independent computational technqiues, molecular docking and bioinformatics sequence analysis (PACMANS), to predict potential binding intera

SUBMITTER: Ferrall-Fairbanks MC 

PROVIDER: S-EPMC5818743 | biostudies-literature | 2018 Mar

REPOSITORIES: biostudies-literature