Association of interleukin-6 polymorphisms with obesity or metabolic traits in young Mexican-Americans.

ABSTRACT:

Objective

The objective of the study is to investigate the association of interleukin-6 (IL6) promoter single-nucleotide polymorphisms rs1800797 (-597 G/A) and rs1800796 (-572 G/C) with obesity or metabolic syndrome in Mexican-Americans.

Methods

The rs1800797 and rs1800796 single-nucleotide polymorphisms were genotyped in Mexican-Americans (n = 437) from South Texas, and results were correlated with measures of obesity and metabolic syndrome including body mass index, waist circumference, blood pressure, cholesterol, triglycerides, glucose, liver enzymes, plasma IL6 and high-sensitive C-reactive protein (hs-CRP).

Results

Significant associations were found for the rs1800796 variant with increased waist circumference, insulin resistance, lower IL6 levels and higher hs-

SUBMITTER: Boeta-Lopez K 

PROVIDER: S-EPMC5818745 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature