Effect of Magnesium Oxide Supplementation on Nocturnal Leg Cramps: A Randomized Clinical Trial.

ABSTRACT:

Importance

Magnesium supplements are widely marketed for prophylaxis of nocturnal leg cramps (NLC) despite no evidence of significant benefit.

Objective

To determine whether magnesium oxide is better than placebo for NLC prophylaxis.

Design, setting, and participants

A randomized, double-blind, placebo-controlled clinical trial of 2 weeks eligibility screening followed by 4 weeks of treatment was conducted in northern Israel, from February to October 2013. An intention-to-treat data analysis was performed from March 22, 2014, to April 17, 2016. We used a volunteer sample of community-dwelling individuals experiencing NLC, 21 years or older, with 4 or more documented episodes of NLC during 2 weeks of screening.

Interventions

Capsules containing either magnesium

SUBMITTER: Roguin Maor N 

PROVIDER: S-EPMC5818780 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature