Association of Biotin Ingestion With Performance of Hormone and Nonhormone Assays in Healthy Adults.

ABSTRACT:

Importance

Biotinylated antibodies and analogues, with their strong binding to streptavidin, are used in many clinical laboratory tests. Excess biotin in blood due to supplemental biotin ingestion may affect biotin-streptavidin binding, leading to potential clinical misinterpretation. However, the degree of interference remains undefined in healthy adults.

Objective

To assess performance of specific biotinylated immunoassays after 7 days of ingesting 10 mg/d of biotin, a dose common in over-the-counter supplements for healthy adults.

Design, setting, and participants

Nonrandomized crossover trial involving 6 healthy adults who were treated at an academic medical center research laboratory.

Exposure

Administration of 10 mg/d of biotin supplementation for 7 days.

SUBMITTER: Li D 

PROVIDER: S-EPMC5818818 | biostudies-literature | 2017 Sep

REPOSITORIES: biostudies-literature