Association of Intensive Blood Pressure Control and Kidney Disease Progression in Nondiabetic Patients With Chronic Kidney Disease: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

The optimal blood pressure (BP) target remains debated in nondiabetic patients with chronic kidney disease (CKD).

Objective

To compare intensive BP control (<130/80 mm Hg) with standard BP control (<140/90 mm Hg) on major renal outcomes in patients with CKD without diabetes.

Data sources

Searches of PubMed, MEDLINE, Embase, and Cochrane Library for publications up to March 24, 2016.

Study selection

Randomized clinical trials that compared an intensive vs a standard BP target in nondiabetic adults with CKD, reporting changes in glomerular filtration rate (GFR), doubling of serum creatinine level, 50% reduction in GFR, end-stage renal disease (ESRD), or all-cause mortality.

Data extraction and synthesis

Random-effects meta-analyses for pooling e

SUBMITTER: Tsai WC 

PROVIDER: S-EPMC5818822 | biostudies-literature | 2017 Jun

REPOSITORIES: biostudies-literature